A double-blind, placebo controlled trial involving 156 patients with osteoporosis found that supplementing with pycnogenol - an extract of pine bark - significantly reduced many of the symptoms associated with medications used to treat osteoporosis. Specifically, there was a 58% reduction in pain, there was increased walking distance on a treadmill test, decreased gastrointestinal complications (63% reduction), and decreased foot edema (79% reduction in the treatment group vs 1% in the placebo group).
The study used 100mg of pycnogenol daily for 3 months.
"Treatment of osteoarthritis with Pycnogenol(®). The SVOS (San Valentino osteo-arthrosis study). Evaluation of signs, symptoms, physical performance and vascular aspects," Belcaro G, Cesarone MR, et al, Phytotherapy Research, 2008; 22(4): 518-23.
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